Highly Aligned Skeletal Muscle Fibers
نویسندگان
چکیده
We propose highly aligned skeletal muscle fibers (Fig.1). We found that the textiles of a fibrin hydrogel fiber are highly orientated to the the longitudinal direction of the fiber by using a micro fluidic channel of a micro glass capillary tube. We also confirmed that the seeded skeletal muscle cells, C2C12, migrated into the fiber and aligned to the fiber direction without any complex lithographic patterning. Furthermore, the skeletal muscle cells in the fiber were differentiated to multinucleus myotubes. As a demonstration, we engineered artificial finger models by integrating our bundle and stretched skeletal muscle fibers to biocompatible polymer fingers. We believe that this would be an essential step to fabricate a soft material finger driven by the contraction of highly aligned skeletal muscle cells.
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